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Nanotechnology is novel drug delivery systems used for efficient and targeted delivery of drugs. Nanoparticles are colloidal in nature and in fall in the size range of 10-1000nm.Natural polymers like xyloglucan can be used for formulation of nanoparticles using ionic gelation technique. The hydrophilicity of xyloglucan decreases the opsonization of nanoparticles in systemic circulation. This technique can be used to formulate nanoparticles of BCS class III and class IV drugs and help improve their permeability and solubility. The formulated nanoparticles will be characterized by Zetasizer, X-Ray diffraction, Scanning electron microscopy. Key words- Nanoparticles, Xyloglucan.