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Corpora amylacea (CA), beta amyloid plaques and neurofibrillary tangles are brain lesions commonly associated with dementia and aging. An uncertainty of the effects and causes of clinical presentations from these lesions still exists. In this study, we examine brains from cadavers with and without neurocognitive disease (ND) to investigate any existing associations between lesions found and the diagnosed cause of death. More specifically, we identify the location and number of corpora amylacea within the posterior temporal lobe and cerebellum at the level of the fourth ventricle. Brains with a cause of death due to ND were found to have less CA in the perivasculature and submeningeal areas when compared to brains that did not have neurocognitive disease. This study provides new insights on CA in the role of aging and ND. Due to the small sample size of this study more research would be needed to reinforce these findings.
