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Friday, March 27 • 09:00 - 17:00
Enzymatic Dynamic Kinetic Resolution for the Stereoselective Synthesis of Alpha-Hydroxy Ketones

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Thiamine diphosphate-dependent enzymes have been explored for their ability to produce alpha-hydroxy ketones with high levels of enantioselectivity. Less explored, however, is the ability of these enzymes to control the configuration about multiple chiral centers. This project focuses on developing an enzymatic dynamic kinetic resolution of racemic substrates to produce alpha-hydroxy ketones with high enantio- and diastereoselectivity and high yield. We have successfully synthesized the substrates, with characterization of the enzymes in these reactions forthcoming. This work will provide an efficient and green approach to synthesize valuable alpha-hydroxy ketone products as precursors to pharmaceuticals and other important molecules.

Friday March 27, 2020 09:00 - 17:00 EDT