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Esophageal cancer is among the most common and the sixth leading cause of cancer related death. During cadaveric dissection of a 77-year-old white male whose cause of death was listed as esophageal cancer, masses were found in the brain and adrenal gland. Histopathologic examination confirmed the masses to be EAC. Here we present a case of metastatic esophageal adenocarcinoma and discuss potential risk factors for tumor development.