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Friday, March 27 • 08:00 - 17:00
[VIRTUAL] Determination of the Mechanism of Action of Synthetic Cannabinoids (sCB) in Human Platelets

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Synthetic cannabinoids (sCB) originated from the scientific community, but are now manufactured by unauthorized people to achieve similar psychoactive effects as natural cannabinoids like tetrahydrocannabinol (THC). Since sCB show worse adverse effects than THC and result in higher emergency medical treatments, it is crucial to understand their mechanism of action. Historical data show that sCB inhibit platelet aggregation and secretion. More recent data with pertussis toxin-treated platelets suggest that sCB do not act through cannabinoid-binding G protein-coupled receptors CB1 or CB2. Therefore, our hypothesis is that sCB act as platelet inhibitors through an unknown mechanism independent of these receptors.

Friday March 27, 2020 08:00 - 17:00 EDT